HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluoronitrobenzene → Ethyl 6-bromo-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluoronitrobenzene | HCID 67967 | — |
| Reactant | Ethyl 6-bromo-2-aminobenzo[b]thiophene-3-carboxylate | HCID 18422163 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ethyl 6-bromo-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422148 | 77.7% |
Reaction Steps
In the same manner as in Starting Material Synthesis Example 4 and using ethyl 6-bromo-2-aminobenzo[b]thiophene-3-carboxylate (8.8 g), 2,4-difluoronitrobenzene (5.6 g) and dimethyl sulfoxide (100 ml), ethyl 6-bromo-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate (10 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271225B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-9af5125668ec4ac58507b58c180803fd |
| Source note | uspto-grants-2001_08 |