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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 649921Generated: October 29, 2026

Ethyl 6-bromo-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate → Ethyl 6-bromo-2-(2-amino-5-fluoroanilino)benzo[b]thiophene-3-carboxylate

https://huagongshe.com/reaction/649921

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 6-bromo-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylateHCID 18422148—
ReactantHCID 178418361HCID 178418361—
CatalystHCID 178418390HCID 178418390—
SolventEthyl AcetateHCID 8857—
ProductEthyl 6-bromo-2-(2-amino-5-fluoroanilino)benzo[b]thiophene-3-carboxylateHCID 18422173—

Reaction Steps

In addition, in the same manner as in Starting Material Synthesis Example 19 and using ethyl 6-bromo-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate, ethyl acetate, 10% palladium-carbon and hydrogen (60 atm kg/cm2), ethyl 6-bromo-2-(2-amino-5-fluoroanilino)benzo[b]thiophene-3-carboxylate is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06271225B1
Source datasetuspto-grants-2001_08
ORD IDord-0a853732418d456ab616cde8e47d673a
Source noteuspto-grants-2001_08