HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 8-chloro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Ethyl 2-(2-amino-5-chloroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422169 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Anisole | HCID 7519 | — |
| Product | 8-chloro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 18422155 | — |
Reaction Steps
In the same manner as in Example 1 and using ethyl 2-(2-amino-5-chloroanilino)benzo[b]thiophene-3-carboxylate (2.6 g), 1-methylpiperazine (15 ml), anisole (50 ml) and titanium tetrachloride (2.3 ml), 8-chloro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine (363 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271225B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-037e7abcff87413cb63a6e94b4d33454 |
| Source note | uspto-grants-2001_08 |