참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tetramethyl orthocarbonate | HCID 74613 | — |
| 반응물 | 2-Aminobenzohydroxamic acid | HCID 79721 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Hydroxy-2-methoxyquinazolin-4(3H)-one | HCID 15582710 | 60% |
반응 단계
A mixture of 22.8 g (0.15 mol) of o-aminobenzohydroxamic acid, 50 ml of methanol and 27.2 g (0.2 mol) of orthocarbonic acid tetramethyl ester was boiled under reflux for 2 hours and was then cooled to 5° C. The product which had crystallized out was filtered off with suction. 17 g (60% of theory) of 2-methoxy-3-hydroxy-3,4-dihyro-4-oxo-quinazoline were obtained in the form of colorless crystals having a melting point of 220° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04612305 |
|---|
| 출처 데이터셋 | uspto-grants-1986_09 |
|---|
| ORD ID | ord-0c54b1ea714148a496fa7a4b18046342 |
|---|
| 출처 메모 | uspto-grants-1986_09 |
|---|
