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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 649950Generated: October 30, 2026

2,5-Difluoronitrobenzene → 2-(4-Fluoro-2-nitroanilino)benzo[b]thiophene-3-carbonitrile

https://huagongshe.com/reaction/649950

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-DifluoronitrobenzeneHCID 67767—
Reactant2-Amino-1-benzothiophene-3-carbonitrileHCID 23273581—
Product2-(4-Fluoro-2-nitroanilino)benzo[b]thiophene-3-carbonitrileHCID 1842229893.1%

Reaction Steps

In the same manner as in Starting Material Synthesis Example 51 and using 2-aminobenzo[b]thiophene-3-carbonitrile (4.0 g) and 2,5-difluoronitrobenzene (3.7 g), 2-(4-fluoro-2-nitroanilino)benzo[b]thiophene-3-carbonitrile (6.7 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06271225B1
Source datasetuspto-grants-2001_08
ORD IDord-7302d0442ec44ef18f872662099af935
Source noteuspto-grants-2001_08