HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-bromo-4,5,6,7-tetrahydro-N-(4-fluoro-2-hydroxyphenyl)-benzo[b]thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Amino-5-fluorophenol | HCID 185763 | — |
| Reactant | 2-Bromo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | HCID 18422137 | — |
| Product | 2-bromo-4,5,6,7-tetrahydro-N-(4-fluoro-2-hydroxyphenyl)-benzo[b]thiophene-3-carboxamide | HCID 18422255 | — |
Reaction Steps
In the same manner as in Starting Material Synthesis Example 60 and using 2-bromo4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, thionyl chloride and 2-amino-5-fluorophenol, 2-bromo-4,5,6,7-tetrahydro-N-(4-fluoro-2-hydroxyphenyl)-benzo[b]thiophene-3-carboxamide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271225B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-13049b4fbc8c496f93ff5221f405a4f4 |
| Source note | uspto-grants-2001_08 |