HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 8-Fluoro-1,2,3,4-tetrahydro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzoxazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 8-fluoro-1,2,3,4-tetrahydro-[1]benzothieno[2,3-b][1,5]benzoxazepin-12(11H)-one | HCID 18422361 | — |
| Product | 8-Fluoro-1,2,3,4-tetrahydro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzoxazepine | HCID 18422294 | — |
Reaction Steps
In the same manner as in Example 80 and using 8-fluoro-1,2,3,4-tetrahydro-[1]benzothieno[2,3-b][1,5]benzoxazepin-12(11H)-one, phosphorus oxychloride, N,N-dimethylaniline and 1-methylpiperazine, 8-fluoro-1,2,3,4-tetrahydro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzoxazepine is obtained. STARTING MATERIAL SNYTHESIS EXAMPLE 66
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271225B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-76b914260e104b3c8ce33f8e0a737fd2 |
| Source note | uspto-grants-2001_08 |