HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 12-(4-Methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | [1]benzothieno[2,3-b][1,5]benzothiazepin-12(11H)-one | HCID 18422154 | — |
| Product | 12-(4-Methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepine | HCID 18422309 | — |
Reaction Steps
In the same manner as in Example 80 and using [1]benzothieno[2,3-b][1,5]benzothiazepin-12(11H)-one (500 mg), phosphorus oxychloride (6.3 g), N,N-dimethylaniline (109 mg) and 1-methylpiperazine (5 ml), 12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepine (278 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271225B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-818fe5caf9ba47e6a6e9c04929c28f50 |
| Source note | uspto-grants-2001_08 |