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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 649979Generated: October 29, 2026

N,N-Dimethylaniline → 8-Fluoro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepine

https://huagongshe.com/reaction/649979

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,N-DimethylanilineHCID 949—
ReactantPhosphorus oxychlorideHCID 24813—
Reactant1-MethylpiperazineHCID 53167—
ReactantHCID 18422231HCID 18422231—
Product8-Fluoro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepineHCID 18422295—

Reaction Steps

In the same manner as in Example 80 and using 8-fluoro-[1]benzothieno[2,3-b][1,5]benzothiazepin-12(11H)-one, phosphorus oxychloride, N,N-dimethylaniline and 1-methylpiperazine, 8-fluoro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepine is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06271225B1
Source datasetuspto-grants-2001_08
ORD IDord-9af6a85ac8384fe596a200df9dd58ed3
Source noteuspto-grants-2001_08