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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 649982Generated: October 30, 2026

N,N-Dimethylaniline → 8-Fluoro-1,2,3,4-tetrahydro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepine

https://huagongshe.com/reaction/649982

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,N-DimethylanilineHCID 949—
ReactantPhosphorus oxychlorideHCID 24813—
Reactant1-MethylpiperazineHCID 53167—
Reactant8-fluoro-1,2,3,4-tetrahydro-[1]benzothieno[2,3-b][1,5]benzothiazepin-12(11H)-oneHCID 18422265—
Product8-Fluoro-1,2,3,4-tetrahydro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepineHCID 18422374—

Reaction Steps

In the same manner as in Example 80 and using 8-fluoro-1,2,3,4-tetrahydro-[1]benzothieno[2,3-b][1,5]benzothiazepin-12(11H)-one, phosphorus oxychloride, N,N-dimethylaniline and 1-methylpiperazine, 8-fluoro-1,2,3,4-tetrahydro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepine is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06271225B1
Source datasetuspto-grants-2001_08
ORD IDord-bd0098f58d554c1fb1a23ae676da3c3d
Source noteuspto-grants-2001_08