Water → HCID 10977719, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(2-hydroxy-4-methylphenyl)-2-bromo-3-thiophenecarboxamide (3.4 g) in dimethyl sulfoxide (30 ml) was added potassium carbonate (2.9 g) and the mixture was stirred at 140-1500° C. for 1 hour. The reaction system was cooled to room temperature and the reaction mixture was poured into water. The precipitated crystals were collected by filtration, washed with water and purified by silica gel column chromatography (chloroform) to give 2,8-dimethylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one (1.2 g).

Provenance & Evidence