HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → N-(aminoiminomethyl)-5,6,7,8-tetrahydro-11-hydroxymethyl-8-oxo-4H-azocino[3.2.1-hi]indole-2-carboxamide methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | ethyl 5,6,7,8-tetrahydro-11-acetoxymethyl-8-oxo-4H-azocino[3.2.1-hi]indole-2-carboxylate | HCID 70235751 | — |
| Reactant | Indole-2-carboxamide methanesulfonate | HCID 86754736 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(aminoiminomethyl)-5,6,7,8-tetrahydro-11-hydroxymethyl-8-oxo-4H-azocino[3.2.1-hi]indole-2-carboxamide methanesulfonate | HCID 136340739 | — |
Reaction Steps
In accordance with the process described in Example 1 except for using ethyl 5,6,7,8-tetrahydro-11-acetoxymethyl-8-oxo-4H-azocino[3.2.1-hi]indole-2-carboxylate (2.13 g, 6.20 mmol), guanidine hydrochloride (5.92 g, 62 mmol), sodium methoxide (3.35 g, 62 mmol) and N,N-dimethylformamide (50 ml), 1.07 g of N-(aminoiminomethyl)-5,6,7, 8-tetrahydro-11-hydroxymethyl-8-oxo-4H-azcino[3.2.1-hi]indole-2-carboxamide methanesulfonate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271251B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-8a1302d365f54bd8809617609eb0a465 |
| Source note | uspto-grants-2001_08 |