2-Amino-5-Nitrophenol → HCID 54257899, compound

HRID 650092Notes

Reaction equation

HRID 650092 reaction equation
[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:12][C@@H:13]([N:20]=[C:21]=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:21]([NH:20][C@H:13]([CH3:12])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:22]

Participants

3

Reactant 2

HCID 49847212-Amino-5-NitrophenolHCID 7018262(R)-(+)-1-Phenylethyl isocyanate

Product 1

HCID 54257899HCID 54257899, compoundYield 71%

Procedure

(R)-N-(2-Hydroxy4-nitrophenyl)-N′-(methylbenzyl)urea was prepared from 2-hydroxy 4-nitro aniline (308 mg, 2.0 mmol) and (R)-methyl benzyl isocyanate (2 mmol) according to the procedure in General Method A. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (427 mg, 71%). EI-MS m/z 300(M−H)−

Workup

  1. customThe product was purified by dilution with methylene chloride and precipitation with hexanes
  2. filtrationFiltering

Sources & evidence

ORD record
ord-8e8f14e9ab454490a977f4f47cf58363
Source dataset
uspto-grants-2001_08
Patent number
US06271261B1

Reaction notes

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