(S)-(-)-1-Phenylethyl isocyanate → (S)-N-(2-hydroxy-4-nitrophenyl)-N'-(methyl benzyl)urea

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Reaction Steps

(S)-N-(2-Hydroxy-4-nitrophenyl)-N′-(methylbenzyl)urea was prepared from 2-hydroxy 4-nitro aniline (308 mg, 2.0 mmol) and (S)-methyl benzyl isocyanate (2 mmol) according to the procedure in General Method A. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (462 mg, 76%). EI-MS m/z 300(M−H)−

Provenance & Evidence