Benzhydrylamine → HCID 21714400, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of aminodiphenylmethane (200 mg, 1.09 mmol) in toluene, triethylamine (0.18 ml, 1.11 mmol) and triphosgene (129.4 mg, 0.44 were added. The reaction mixture was stirred at 80° C. for 3 hours. It was cooled to room temperature and all solvent was evaporated. Then 2-amino5-nitrophenol (168 mg, 1.09 mmol) in DMF (2 mL) was added. The reaction mixture was stirred at 80° C. for 16 hours, then cooled to room temperature. Chromatography of the resulting liquid on silica gel (hexane:ethyl acetate; 1:1) gave product (210 mg, 53%). m.p: 237.4-237.9° C.; EI-MS m/z 364 (M+H)+.

Provenance & Evidence