反应详情

An aqueous solution of sodium borohydride (8.2 g, 50 ml) is added to a stirred solution of the product obtained in Step 3. (41.8 g) in ethanol (1 l) and the mixture refluxed for 3 hours and evaporated in vacuo. The residue is taken up in water and toluene, the layers are separated and the organic phase washed, dried and evaporated in vacuo affording an oil which is dissolved in methylene chloride, dried, filtered and evaporated in vacuo. The residue is dissolved in ethyl acetate and chromatographed on silica gel affording the desired product as a white solid.

1. customevaporated in vacuo
2. customtoluene, the layers are separated
3. washthe organic phase washed
4. customdried
5. customevaporated in vacuo
6. customaffording an oil which
7. customdried
8. filtrationfiltered
9. customevaporated in vacuo
10. dissolutionThe residue is dissolved in ethyl acetate
11. customchromatographed on silica gel affording the desired product as a white solid