N-Methyl-4-pyridone → 4-(1,2,5,6-tetrahydro-1-methyl-4-pyridinyl)-1,3-dimethyl 5-(1H)-pyrazolamine

HRID 65015Notes

Reaction equation

HRID 65015 reaction equation
[CH3:1][N:2]1[CH:7]=[CH:6][C:5](=O)[CH:4]=[CH:3]1.[CH3:9][N:10]1[C:14]([NH2:15])=[CH:13][C:12]([CH3:16])=[N:11]1>>[CH3:1][N:2]1[CH2:7][CH2:6][C:5]([C:13]2[C:12]([CH3:16])=[N:11][N:10]([CH3:9])[C:14]=2[NH2:15])=[CH:4][CH2:3]1

Participants

3

Reactant 2

HCID 136515N-Methyl-4-pyridoneHCID 5207211,3-Dimethyl-1H-pyrazol-5-amine

Product 1

HCID 133521964-(1,2,5,6-tetrahydro-1-methyl-4-pyridinyl)-1,3-dimethyl 5-(1H)-pyrazolamine

Procedure

1-Methyl-4-pyridinone (1.1 mole) is added to 1,3-dimethyl-5-pyrazolamine (1 mole). The reaction mixture is kept at a temperature between 70° C. and 80° C. for a period of about 8 hours. After distillation under vacuum the residue is poured into water and neutralized with NaOH 10%. The compound of the title is recovered by filtration. M.p. 262°-265° C.

Workup

  1. distillationAfter distillation under vacuum the residue
  2. additionis poured into water and neutralized with NaOH 10%
  3. filtrationThe compound of the title is recovered by filtration

Sources & evidence

ORD record
ord-3b38ebaffbb746fc913cc6edd3b81482
Source dataset
uspto-grants-1986_09
Patent number
US04612318

Reaction notes

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