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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 650224Generated: October 30, 2026

Hydrochloric Acid → Tetrahydrofolic acid

https://huagongshe.com/reaction/650224

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant6R-Tetrahydrofolic acidHCID 135415876—
ProductTetrahydrofolic acidHCID 135444742—

Reaction Steps

After subsequently slowly bringing the pH to 4.4 using hydrochloric acid and maintaining this value, 42.0 g of crystalline (6R)-tetrahydrofolic acid with a chemical content of 96.2% and a (6R) percentage of 99.5 are obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06271374B1
Source datasetuspto-grants-2001_08
ORD IDord-ea388b5aa6654286a07ec68830447495
Source noteuspto-grants-2001_08