HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 21714030, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | HCID 21560562 | HCID 21560562 | — |
| Catalyst | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 21714030 | HCID 21714030 | 77% |
Reaction Steps
N-Benzyloxycarbonylphenylglycinal (1.38 g, 5.12 mmol) was dissolved in methanol (2.6 ml), and trimethyl orthoformate (1.12 ml, 10.24 mmol) and camphor sulfonic acid (59.5 mg, 0.256 mmol) were added to it and stirred overnight at room temperature. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by column chromatography on alumina (50 g alumina, hexane/ethyl acetate=2/1) whereby the title compound (1.21 g, 77% yield) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271238B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-589ad9bfb9ef42aa9fc472863eb17792 |
| Source note | uspto-grants-2001_08 |