1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 70236790, compound

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Reaction Steps

2-(5-t-Butyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-{2-hydroxy-3-oxo-6-(2-oxo-1,2-dihydropyridine-1-yl)-1-phenylmethyl}hexylacetamide (115 mg, 0.18 mmol) was dissolved in dimethylsulfoxide (2 ml), under argon atmosphere, and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (103 mg, 0.54 mmol) and pyridinium trifluoroacetate (17 mg, 0.1 mmol) were added to it, and the mixture was stirred for 3.5 hours. The reaction solution was diluted with ethyl acetate and washed successively with distilled water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol=30/1), and thereafter hexane was added to it to precipitate solid. The precipitated solid was collected by filtration whereby the title compound (96 mg, 83% yield) was obtained.

Provenance & Evidence