p-Toluenesulfonic acid → HCID 21714039, compound

Participants

Reaction Steps

3-t-Butyloxycarbonyl-2,2-dimethyl-5-(1-oxoethyl)-4-(3-fluorophenyl)methyloxazolidine (17.94 g, 51.1 mmol) was dissolved in ethanol (180 ml), and p-toluenesulfonic acid.1H2O (10.7 g, 56.2 mmol) was added to it and the mixture was heated under reflux for 2 hours with stirring. The reaction solution was concentrated under reduced pressure, and the resulting residue was dried with a vacuum pump (2 mmHg) at 50° C., whereby crude 2-amino-1-(3-fluorophenyl)-3-hydroxy-4-oxopentane p-toluenesulfonate (21.5 g) was obtained as solid. This solid was subjected without further purification to the subsequent condensation reaction.

Provenance & Evidence