Water → HCID 15544616, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium thiocyanate (7.5 g) in 50 ml of methanol was cooled to −76° C. Bromine in 30 ml of cold methanol was added dropwise over 12 min. A slurry of 2-chloro-3-cyano-5-methylpyrrole in 30 ml of cold methanol was added at once. After stirring 30 min at −78° C., the mixture was poured into H2O and stirred overnight, then filtered, washed with water and hexane, and air dried to afford 6.57 g of an off-white solid, m.p. 171° C.

Provenance & Evidence