反应详情

In 40 ml of acetonitrile was dissolved 516 mg of thiourea. In the solution was suspended 2.5 g of 2-bromo-1-(4-methoxyphenyl)-2-(3-pyridyl)-ethanone hydrobromide. To the suspension was added dropwise slowly 0.95 ml of triethylamine while stirring. The mixture was stirred for 3 hours at a refluxing temperature, which was then left standing for cooling. Precipitating crystals were collected by filtration. The crystals were washed with an aqueous solution of saturated hydrogen carbonate, water, ethanol and ethylether in that order, followed by drying. The crystals were recrystallised from tetrahydrofuran to yield 1.5 g (90%) of 2-amino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol, m.p. 265°-266° C.

1. stirringThe mixture was stirred for 3 hours at a refluxing temperature, which
2. waitwas then left standing
3. temperaturefor cooling
4. customPrecipitating crystals
5. filtrationwere collected by filtration
6. washThe crystals were washed with an aqueous solution of saturated hydrogen carbonate, water, ethanol and ethylether in that order
7. customby drying
8. customThe crystals were recrystallised from tetrahydrofuran