HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 7a-(5-Hydroxypentyl)-estr-4-ene-3,17-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 7alpha-(5-Tert-butyldimethylsilyloxypentyl)-estr-4-ene-3,17-dione | HCID 22941811 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7a-(5-Hydroxypentyl)-estr-4-ene-3,17-dione | HCID 15838156 | 99% |
Reaction Steps
A solution of 125.4 g of 7α-(5-tert-butyldimethylsilyloxypentyl)-estr-4-ene-3,17-dione in 625 ml of methanol and 347 ml of water is stirred with 694 ml of glacial acetic acid for 2.5 hours at 50° C. After the concentration by evaporation at 60° C. in a vacuum, 94.1 g of crude 7α-(5-hydroxypentyl)-estr-4-ene-3,17-dione is obtained as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271403B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-11652617edc246d0a48c70c96623fb5f |
| Source note | uspto-grants-2001_08 |