Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 7a-(5-Hydroxypentyl)-estr-4-ene-3,17-dione | HCID 15838156 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 15838157 | HCID 15838157 | — |
Reaction Steps
A solution of 94 g of crude 7a-(5-hydroxypentyl)-estr-4-ene-3,17-dione in 620 ml of pyridine is slowly mixed with 310 ml of acetic anhydride and stirred for 2 hours at 25° C. Then, it is slowly mixed with 116 mnl of water while being cooled with ice, diluted with 3 l of diethyl ether, the organic phase is dried and concentrated by evaporation after washing with sodium bicarbonate solution. The residue is chromatographed on silica gel, and 84.4 g of 7α-(5-acetoxypentyl)-estr-4-ene-3,17-dione is obtained as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06271403B1 |
|---|
| Source dataset | uspto-grants-2001_08 |
|---|
| ORD ID | ord-643ebed33d884889868e18645457c839 |
|---|
| Source note | uspto-grants-2001_08 |
|---|
