p-Toluenesulfonic acid → Estra-1,3,5(10),15-tetraen-17-one

Participants

Reaction Steps

A solution of 36.12 g of 17,17-ethylenedioxy-7α-(5-hydroxypentyl)-estra-1,3,5(10),15-tetraen-3-ol in 958 ml of acetone and 111 ml of water is stirred for 2 hours at room temperature with 2.76 g of para-toluenesulfonic acid. Then, it is concentrated by evaporation in a vacuum to ⅓ of the volume, taken up with ethyl acetate, washed neutral, dried on sodium sulfate and concentrated by evaporation in a vacuum. 31.7 g of 3-hydroxy-7α-5-hydroxypentyl)-estra- 1,3,5(10),15-tetraen- 17-one is obtained as crystals with a melting point of 194-196° C.

Provenance & Evidence