反应详情

In 40 ml of acetonitrile was dissolved 1.12 g of benzyloxycarbonylaminothioacetamide. In the solution was suspended 2.0 g of 2-bromo-1-(4-methoxyphenyl)-2-(3-pyridyl)ethanone hydrobromide. To the suspension was added while stirring 0.8 ml of triethylamine. The mixture was stirred for 2 hours under reflux. The resultant was left standing for cooling, then the solvent was evaporated off. To the residue was added a saturated aqueous solution of sodium hydrogen carbonate. The mixture was subjected to extraction with ethyl acetate. The extract solution was washed with water, dried and, then, the solvent was evaporated off. The residue was recrystallized from ethyl acetate-isopropylether to give 1.3 g (yield 56%) of 2-(benzyloxycarbonylaminomethyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole, m.p. 93°-94° C.

1. additionTo the suspension was added
2. temperatureunder reflux
3. waitThe resultant was left
4. temperaturefor cooling
5. customthe solvent was evaporated off
6. additionTo the residue was added a saturated aqueous solution of sodium hydrogen carbonate
7. extractionThe mixture was subjected to extraction with ethyl acetate
8. washThe extract solution was washed with water
9. customdried
10. customthe solvent was evaporated off
11. customThe residue was recrystallized from ethyl acetate-isopropylether