反应详情

In 20 ml of acetic acid was dissolved 4.3 g of 1-(5-indanyl)-2-(3-pyridyl)ethanone. To the solution was added 0.93 ml of bromine, which was stirred for one hour at 80°, then the reaction solution was cooled. Addition of 80 ml of ethylether gives a layer of oily substance. The supernatant was discorded, and the remainder was dissolved in 50 ml of acetonitrile. The solution was cooled to give 6.2 g of 2-bromo-1-(5-indanyl)-2-(3-pyridyl)ethanone hydrobromide, m.p. 176°-177° C. The yield was 86%.

1. temperaturethe reaction solution was cooled
2. customgives a layer of oily substance
3. temperatureThe solution was cooled