Carbon Disulfide → Sodium (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate

Participants

Reaction Steps

To a mixture of (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline (5.06 g), CS2 (2.0 g) and ethanol (230 ml) is added dropwise a 1N NaOH solution (25 ml) at room temperature. The mixture is stirred for 2 hours, and thereto is added ethanol. The precipitated crystals are collected by filtration and recrystallized from water-ethanol to give the title compound (5.3 g, 71%) as colorless needles, m.p. 209°-210° C. (decomp.), [α]D20 +151.8° (c=1, methanol).

Provenance & Evidence