N-Methylisatoic anhydride → HCID 21712106, compound

HRID 650466Notes

Reaction equation

HRID 650466 reaction equation
Cl.[CH2:2]([O:9][NH2:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:11][N:12]1C(=O)O[C:15](=[O:16])[C:14]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:13]12>>[CH3:11][NH:12][C:13]1[CH:23]=[CH:22][CH:21]=[CH:20][C:14]=1[C:15]([NH:10][O:9][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)=[O:16]

Participants

3

Reactant 2

HCID 25160N-Methylisatoic anhydrideHCID 102312Benzyloxyamine hydrochloride

Product 1

HCID 21712106HCID 21712106, compoundYield 29.3%

Procedure

In the same manner as Example 35(a), O-benzylhydroxylamine hydrochloride (1.92 g, 12 mmol) reacted with N-methylisatoic anhydride (2.0 g, 10 mmol) to give 2-methylamino-N-benzyloxylbenzamide as a yellow solid (0.75 g).

Sources & evidence

ORD record
ord-9363f7145e024b0d9d23ac8f61101c98
Source dataset
uspto-grants-2001_08
Patent number
US06274383B1

Reaction notes

Loading…