HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Cyano-4-(2-methylphenyl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-cyano-4-(2-methylphenyl)piperidine-1-carboxylate | HCID 22625983 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Cyano-4-(2-methylphenyl)piperidine hydrochloride | HCID 21712248 | — |
Reaction Steps
A solution of EtOAc saturated with HCl (200 ml) was added to 4-cyano-N-(1,1-dimethylethoxy)carbonyl-4-(2-methylphenyl)piperidine (31 mg, 0.097 mmol). The resulting mixture was allowed to react for 1 hour at room temperature. The EtOAc was removed in vacuo affording 4-cyano-4-(2-methylphenyl)piperidine hydrochloride as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06274583B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-081f0baccb824eb58115d63d00a0791e |
| Source note | uspto-grants-2001_08 |