反应详情

A solution of di-p-tolylacetic acid (4.90 g, 20.4 mmol) in methanol was treated with sat'd HCl/MeOH solution at room temperature. The mixture was stirred at room temperature (3 h). The solvent was removed in vacuo and the residue dissolved in dichloromethane and sodium bicarbonate solution. The aqueous layer was extracted with two additional portions of dichloromethane and the combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound (21). The crude product was used directly.

1. customThe solvent was removed in vacuo
2. dissolutionthe residue dissolved in dichloromethane
3. extractionThe aqueous layer was extracted with two additional portions of dichloromethane
4. washthe combined organic extracts were washed with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated under reduced pressure