HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 1-(Quinoxalin-6-ylcarbonyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Quinoxaline-6-carboxylic acid | HCID 674813 | — |
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Reactant | 1-(Quinoxalin-6-ylcarbonyl)-1,2,3,6-tetrahydropyridine | HCID 11630079 | — |
| Product | 1-(Quinoxalin-6-ylcarbonyl)piperidine | HCID 148184 | — |
Reaction Steps
The coupling of 6-quinoxalinecarboxylic acid to piperidine is accomplished in a manner similar to that used for the preparation of Invention Compound XIII, or by any other method known in the art for activation of aromatic carboxylic acids, such as, for example, activation by carbonyl diimidazole. 1H NMR δ 1.56 and 1.73 (br, 6), 3.40 (br s, 2), 3.79 (br s, 2), 7.82 (dd, 1, J=8.8, 1.9 Hz), 8.13 (d, 1, J=1.6 Hz), 8.17 (d, 1, 8.6 Hz), and 8.9 ppm (m, 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06274600B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-274ca1495417457fa3ed8eaac95d5212 |
| Source note | uspto-grants-2001_08 |