Acetyl chloride → HCID 18697661, compound

Participants

Reaction Steps

To a mixture of 6-cyano-2,3-dihydrothieno[2,3-b][1,4]thiazine (0.3 g) and triethylamine (0.46 ml) in dichloromethane (10 ml) was dropwise added acetyl chloride (0.23 ml). After stirring for 5 hours at room temperature, the reaction mixture was poured into a mixture of ethyl acetate and water. The organic layer was successively washed with brine and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was pulverized from diisopropyl ether to give 1-acetyl-6-cyano-2,3-dihydrothieno [2,3-b][1,4] thiazine (0.33 g)

Provenance & Evidence