反应详情

温度

80 °C

A mixture of 6-amidino-1-ethoxycarbonylmethyl-2,3-dihydro-2-oxo-1H-thieno[2,3-b][1,4]thiazine hydrochloride (0.15 g) and cHCl (1.5 ml) was stirred at 80° C. for 7 hours. The reaction mixture was evaporated in vacuo. The resulting oil was dissolved with water, and lyophilized to give 6-amidino-1-carboxymethyl-2,3-dihydro-2-oxo-1H-thieno[2,3-b]-[1,4]thiazine hydrochloride (90.6 mg).

1. customThe reaction mixture was evaporated in vacuo
2. dissolutionThe resulting oil was dissolved with water