CID 6432229 → HCID 21712709, compound

HRID 650609Notes

Reaction equation

HRID 650609 reaction equation
[ClH:1].[C:2]([C:5]1[S:20][C:8]2[S:9][CH2:10][C:11](=[O:19])[N:12]([CH2:13][C:14]([O:16]CC)=[O:15])[C:7]=2[CH:6]=1)(=[NH:4])[NH2:3].[CH]Cl>>[ClH:1].[C:2]([C:5]1[S:20][C:8]2[S:9][CH2:10][C:11](=[O:19])[N:12]([CH2:13][C:14]([OH:16])=[O:15])[C:7]=2[CH:6]=1)(=[NH:3])[NH2:4]

Participants

3

Reactant 2

HCID 6432229CID 6432229HCID 21712691HCID 21712691, compound

Product 1

HCID 21712709HCID 21712709, compoundYield 65.9%

Conditions

Temperature
80 °C

Procedure

A mixture of 6-amidino-1-ethoxycarbonylmethyl-2,3-dihydro-2-oxo-1H-thieno[2,3-b][1,4]thiazine hydrochloride (0.15 g) and cHCl (1.5 ml) was stirred at 80° C. for 7 hours. The reaction mixture was evaporated in vacuo. The resulting oil was dissolved with water, and lyophilized to give 6-amidino-1-carboxymethyl-2,3-dihydro-2-oxo-1H-thieno[2,3-b]-[1,4]thiazine hydrochloride (90.6 mg).

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. dissolutionThe resulting oil was dissolved with water

Sources & evidence

ORD record
ord-d4aec633f2cb4c35a85db3e4545fa034
Source dataset
uspto-grants-2001_08
Patent number
US06274619B1

Reaction notes

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