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HRID65062

反应详情

EQUATION

反应方程式

HRID 65062 的结构方程式

REACTANTS

反应物

4
结构：CI
HCID6328

Methyl iodide

CH3I

结构：S=C=S
HCID6348

Carbon disulfide

CS2

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：OC[C@H]1Cc2c([nH]c3ccccc23)[C@H](CO)N1
HCID86741010

未命名化合物

PRODUCTS

生成物

1
结构：CSC(=S)N1[C@@H](CO)Cc2c([nH]c3ccccc23)[C@@H]1CO
HCID86741009

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

In the same manner as described in Example 13 by using (1RS, 3SR)-trans-1,3-dihydroxymethyl-1,2,3,4-tetrahydro-β-carboline (0.65 g), triethylamine (0.79 ml), CS2 (0.34 ml), methyl iodide (0.35 ml) and dimethylsulfoxide (6 ml), there is prepared the title compound (350 mg, 39%) as colorless needles, m.p. 179°-180° C. (recrystallized from water-ethanol). NMR (CDCl3 -DMSO-d6, δ): 2.66 (s, 3H, CSSCH3), Mass m/e: 304 (M+ --H2O), 274 (M+ --CH3SH).

WORKUP

后处理

  1. customis prepared
  2. customthe title compound (350 mg, 39%) as colorless needles, m.p. 179°-180° C. (recrystallized from water-ethanol)