Ethanol → 4-(2-Bromo-phenyl)-2-methyl-pyrimidine-5-carboxylic acid

Participants

Reaction Steps

To a solution of 8.3 g (25.8 mmol) 4-(2-bromo-phenyl)-2-methyl-pyrimidine-5-carboxylic acid ethyl ester in 10 ml ethanol 1.55 g (38.6 mmol) NaOH in 20 ml H2O was added. After stirring for 1 hr., the reaction mixture was washed with 100 ml diethylether. The pH of the aqueous phase was adjusted to 1 with 25% HCl and than extracted twice with 200 ml CH2Cl2. The combined organic layers were dried (MgSO4), filtrated and evaporated to give 7.0 g (92%) 4-(2-bromo-phenyl)-2-methyl-pyrimidine-5-carboxylic acid as a pale yellow foam.

Provenance & Evidence