HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxy-acetamidine hydrochloride → 2-Hydroxymethyl-4-phenyl-pyrimidine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxy-acetamidine hydrochloride | HCID 12217366 | — |
| Reactant | Ethyl-2-benzoyl-3-dimethylaminopropenoate | HCID 54499154 | — |
| Product | 2-Hydroxymethyl-4-phenyl-pyrimidine-5-carboxylic acid | HCID 21712417 | — |
Reaction Steps
In an analogous manner to that described in example 3b) starting from 2-benzoyl-3-dimethylamino-acrylic acid ethyl ester and 2-hydroxy-acetamidine hydrochloride followed by saponification as described in Example 3c), there was obtained 2-hydroxymethyl-4-phenyl-pyrimidine-5-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06274588B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-563aed64921b494a95ff672a12405328 |
| Source note | uspto-grants-2001_08 |