Ammonia → HCID 53812356, compound

HRID 650671Notes

Reaction equation

HRID 650671 reaction equation
N(C1C=C(C2SC(C(NCC([CH2:37][CH2:38][O:39][C:40](=[O:42])[CH3:41])(NS(C3C(C)=CC(C)=CC=3C)(=O)=O)C(N)=O)=O)=CC=2)C=CC=1)C(N)=N.N.N(C1C=C(C2SC(C([NH:61][CH2:62][C:63](CCO)([NH:67][S:68]([C:71]3[C:76]([CH3:77])=[CH:75][C:74]([CH3:78])=[CH:73][C:72]=3[CH3:79])(=[O:70])=[O:69])[C:64]([NH2:66])=[O:65])=O)=CC=2)C=CC=1)C(N)=N>>[NH2:61][CH2:62][CH:63]([NH:67][S:68]([C:71]1[C:72]([CH3:79])=[CH:73][C:74]([CH3:78])=[CH:75][C:76]=1[CH3:77])(=[O:69])=[O:70])[C:64]([NH:66][CH2:37][CH2:38][O:39][C:40](=[O:42])[CH3:41])=[O:65]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 178425959HCID 178425959, compoundHCID 178476279HCID 178476279, compound

Product 1

HCID 53812356HCID 53812356, compound

Procedure

3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbonyl]-amino}-2-(2,4,6-trimethyl-benzenesulfonylamino)-2-acetoxyethyl propionamide (X-9) was treated with excess methanolic ammonia resulting in the formation of 3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbonyl]-amino}-2-(2,4,6-trimethyl-benzenesulfonylamino)-2-hydroxyethyl propionamide (X-9).

Sources & evidence

ORD record
ord-8999a90accf94ad395834e49935ce563
Source dataset
uspto-grants-2001_08
Patent number
US06274620B1

Reaction notes

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