Methanol → HCID 20677630, compound

Participants

Reaction Steps

To a mixture of 3-Benzyloxycarbonylamino-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid 2-tert-butoxycarbonylamino-3-methyl-butyl ester (Z-1) (280 mg, 0.46 mmol methanol (70 ml), was added Pd/C. The reaction was stirred under hydrogen atmosphere overnight at room temperature. Catalyst was removed by filtration and the solvent was evaporated. Purification of the residue on silica gel (1:2 hexane:EtOAc) gave 120 mg (56%) of pure 3-Amino-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid 2-tert-butoxycarbonylamino-3-methyl-butyl ester (Z-2).

Provenance & Evidence