反应详情

温度

0 °C

Hexafluorophosphoric acid (65% in water) is purchased from Fluka and evaporated with pyridine three times to concentrate. A solution of imidazole or benzimidazole (20 mmol) in ether (100 mL) is treated with 20 mmol of evaporated hexafluorophosphoric acid under stirring and at 0° C. After mixing the solution is evaporated and the slurry is treated with anhydrous ether. The salt is isolated by filtration, followed by washing with ether and drying in vacuo.

1. customevaporated with pyridine three times
2. concentrationto concentrate
3. additionAfter mixing the solution
4. customis evaporated
5. additionthe slurry is treated with anhydrous ether
6. customThe salt is isolated by filtration
7. washby washing with ether
8. customdrying in vacuo