HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-[7-[(3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidin-3-yloxymethyl]-naphthalen-2-yloxy]-ethyl]-4-methyl-piperazine → (3R,4R)-4-(4-hydroxy-phenyl)-piperidin-3-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-[7-[(3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidin-3-yloxymethyl]-naphthalen-2-yloxy]-ethyl]-4-methyl-piperazine | HCID 9852582 | — |
| Reactant | (3R,4R)-1-[(1R)-1-Phenylethyl]-4-[4-(phenylmethoxy)phenyl]-3-piperidinol hydrochloride | HCID 69110291 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Product | (3R,4R)-4-(4-hydroxy-phenyl)-piperidin-3-ol hydrochloride | HCID 20677893 | — |
Reaction Steps
Another preferred aspect of the present invention is the transformation of (3R,4R)-4-(4-benzyloxy-phenyl)-1-((R)-1-phenyl-ethyl)-piperidin-3-ol hydrochloride to 1-[2-[7-[(3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidin-3-yloxymethyl]-naphthalen-2-yloxy]-ethyl]-4-methyl-piperazine by the following procedure: a) reacting (3R,4R)-4-(4-benzyloxy-phenyl)-1-((R)-1-phenyl-ethyl)-piperidin-3-ol hydrochloride with hydrogen to yield (3R,4R)-4-(4-hydroxy-phenyl)-piperidin-3-ol hydrochloride;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06274735B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-8187165658cb4c29b93b5ffa61c23d69 |
| Source note | uspto-grants-2001_08 |