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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 650722Generated: October 30, 2026

Sodium hydride → HCID 57135446, compound

https://huagongshe.com/reaction/650722

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant2-Chloromethyl-7-(2-trimethylsilanyl-ethoxymethoxy)-naphthaleneHCID 11163083—
Reactant(3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl esterHCID 11305954—
ProductHCID 57135446HCID 57135446—

Reaction Steps

reacting the product of step c) with 2-chloromethyl-7-(2-trimethylsilanyl-ethoxymethoxy)-naphthalene and sodium hydride to form (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-[7-(2-trimethylsilanyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-piperidine-1-carboxylic acid tert-butylester;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06274735B1
Source datasetuspto-grants-2001_08
ORD IDord-d4431a835dc24ae59a60e0bcb72c9866
Source noteuspto-grants-2001_08