HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(quinolin-7-yl-methoxy)-piperidine-1-carboxylic acid tert-butylester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 11305954 | — |
| Reactant | 7-(Bromomethyl)quinoline--hydrogen bromide (1/1) | HCID 21713086 | — |
| Product | (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(quinolin-7-yl-methoxy)-piperidine-1-carboxylic acid tert-butylester | HCID 57033058 | — |
Reaction Steps
reacting the product of step c) with 7-bromomethyl-quinoline hydrobromide and sodium hydride to yield (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(quinolin-7-yl-methoxy)-piperidine-1-carboxylic acid tert-butylester;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06274735B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-9fd035c123124440b2874523fd2dda19 |
| Source note | uspto-grants-2001_08 |