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Carbon Disulfide → HCID 13392989、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon Disulfide | HCID 6348 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Butyl iodide | HCID 10962 | — |
| 反応物 | (1S, 3S)-3-hydroxymethyl-1-methyl-1,2,3,4-tetrahydro-beta-carboline | HCID 13375562 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 13392989 | HCID 13392989 | 75% |
反応手順
In the same manner as described in Example 34 by using (1S, 3S)-3-hydroxymethyl-1-methyl-1,2,3,4-tetrahydro-β-carboline (1.08 g), triethylamine (1.01 g), CS2 (0.76 g), n-butyl iodide (1.84 g) and dimethylformamide (8 ml), there is prepared the title compound (1.3 g, 75%) as colorless needles, m.p. 110°-113° C. (recrystallized from aqueous ethanol, [α]D20 +181.8° (c=1.0, methanol); NMR (CDCl3, δ): 0.97 (m, 3H, --(CH2)3CH3); Mass m/e: 348 (M+), 258 (M+ --C4H9SH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04612317 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-713b7b57c8b448f0b42a61bec1909fb3 |
| 出典メモ | uspto-grants-1986_09 |