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N-((1R)-2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)-1-((2-naphthyl)methyl)-2-oxoethyl)-N-methylcarbamic acid tert-butyl ester (6.12 g, 13.8 mmol) was dissolved in dichloromethane (40 ml). The solution was cooled to 0° C. Trifluoroacetic acid (40 ml) was added. The reaction mixture was stirred for 90 min at 0° C. Dichloromethane (110 ml) and a saturated aqueous solution of sodium hydrogen carbonate (150 ml) were added successively. Solid sodium hydrogen carbonate was added until pH 7 was obtained The phases were separated. The aqueous phase was extracted with dichloromethane (3×60 ml). The combined organic layers were dried over magnesium sulfate. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (130 g), using dichloromethane/methanol/25% aqueous ammonia 100:10:1 as eluent, to give 2.20 g of (2R)-1-(1,2,3,4 -tetrahydroisoquinolin-2-yl)-2-(methylamino)-3-(2-naphthyl)1-propanone.

1. customwas obtained The phases
2. customwere separated
3. extractionThe aqueous phase was extracted with dichloromethane (3×60 ml)
4. dry with materialThe combined organic layers were dried over magnesium sulfate
5. customThe solvent was removed in vacuo
6. customThe crude product was purified by flash chromatography on silica (130 g)