Sodium Hydroxide → sodium 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate

HRID 65086Notes

Reaction equation

HRID 65086 reaction equation
[C:1]([C:9]1[N:13]2[CH2:14][CH2:15][CH:16]([C:17]([OH:19])=[O:18])[C:12]2=[CH:11][C:10]=1[S:20][CH3:21])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:23]>CO>[C:1]([C:9]1[N:13]2[CH2:14][CH2:15][CH:16]([C:17]([O-:19])=[O:18])[C:12]2=[CH:11][C:10]=1[S:20][CH3:21])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 136875135-Benzoyl-6-(methylsulfanyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Product 1

HCID 23711368sodium 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 300 mg of 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml of methanol is added 1 molar equivalent of sodium hydroxide, in the form of a 0.1N solution. The solvent is evaporated in vacuo and the residue is taken up in 2 ml of methanol, followed by precipitation with ether, to yield crude sodium 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate.

Workup

  1. customThe solvent is evaporated in vacuo
  2. customfollowed by precipitation with ether

Sources & evidence

ORD record
ord-82b01d97c67b4da1a95d0364386c2024
Source dataset
uspto-grants-1986_09
Patent number
US04612325

Reaction notes

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