Carbon Tetrachloride → HCID 21710143, compound

Temperature

25 °C

A stirred solution of 5.9 grams (0.030 mole) of methyl 2-methyl-3-nitrobenzoate and 5.3 grams (0.030 mole) of NBS in 120 mL of carbon tetrachloride was exposed to uv light for about 18 hours. The reaction mixture was cooled and filtered to remove a solid material. The filtrate was concentrated under reduced pressure to a residue. The residue was the intermediate methyl 2-bromomethyl-3-nitrobenzoate, as determined by NMR analysis. The intermediate 2-bromomethyl compound was slowly added to 60 mL of diethyl ether, and the resulting solution was in turn added dropwise to 40 mL of stirred 1-methylethylamine at 25° C. Upon completion of addition, the reaction mixture was stirred at 25° C. for about 18 hours. The reaction mixture was then concentrated under reduced pressure to remove excess 1-methylethylamine. The resultant solid was washed with aqueous dilute hydrochloric acid and dried, yielding 6.0 grams of subject compound, mp 150-152 C. The NMR spectrum was consistent with the proposed structure.

1. customfor about 18 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customto remove a solid material
5. concentrationThe filtrate was concentrated under reduced pressure to a residue
6. additionThe intermediate 2-bromomethyl compound was slowly added to 60 mL of diethyl ether
7. additionadded dropwise to 40 mL of stirred 1-methylethylamine at 25° C
8. additionUpon completion of addition
9. concentrationThe reaction mixture was then concentrated under reduced pressure
10. customto remove excess 1-methylethylamine
11. washThe resultant solid was washed with aqueous dilute hydrochloric acid
12. customdried

ORD record

ord-86c6951ef5c344f3929e7244f059f511

Source dataset

uspto-grants-2001_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06277847B1