HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 650931Generated: October 26, 2026
Trimethyl orthovalerate → 2-(1-n-Butyl-1-methoxymethyleneamino)-thiophene-3-carboxylicacid propylamide
https://huagongshe.com/reaction/650931
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethyl orthovalerate | HCID 83755 | — |
| Reactant | 2-amino-N-propylthiophene-3-carboxamide | HCID 11788675 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(1-n-Butyl-1-methoxymethyleneamino)-thiophene-3-carboxylicacid propylamide | HCID 53928955 | — |
Reaction Steps
In a destillation apparatus, a mixture of 1.84 g of 2-aminothiophene-3-carboxylic-acid propylamide and 2.43 g of trimethyl orthovalerate is heated for 2 hours at 130° C. Methanol, which arises during the reaction is directly distilled out of the reaction flask. After cooling, the crude product is purified by column chromatography (eluant:hexane/ethylacetate=1:2). Yield:1.9 g pure 2-(1-n-butyl-1-methoxymethyleneamino)thiophene-3-carboxylic-acid propylamide; m.p. 68-70° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06277858B1 |
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| Source dataset | uspto-grants-2001_08 |
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| ORD ID | ord-8a79abdb323e46cabeab776212a780a5 |
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| Source note | uspto-grants-2001_08 |
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