HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 650954Generated: October 27, 2026
Isopropyl iodide → Methyl 3-chloro-4-isopropoxybenzoate
https://huagongshe.com/reaction/650954
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3-chloro-4-hydroxybenzoate | HCID 77580 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 3-chloro-4-isopropoxybenzoate | HCID 22597811 | 99.5% |
Reaction Steps
Methyl 3-chloro-4-hydroxybenzoate (5 g, 26.8 mmol) in DMF (45 ml) was treated with potassium carbonate (7.41 g, 53.6 mmol), 2-iodopropane (3.85 ml, 40.2 mmol) and then stirred at 25° C. for 18 h. Work-up with ethyl acetate gave the title compound (6.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06277861B1 |
|---|
| Source dataset | uspto-grants-2001_08 |
|---|
| ORD ID | ord-b0fe985c95f7400aae4821a4b5d1a689 |
|---|
| Source note | uspto-grants-2001_08 |
|---|
